SOFT & STRETCHABLE MICROELECTRODE ARRAYS (sMEAs) WITH 3D POCKET AND MICROFLUIDIC CHANNEL

• Main Authors: Graudejus, Oliver, Ponce Wong, Ruben Dario, Rowan, Cami Caitlyn, Lopez Arellano, Francisco Javier
• Format: Patent
• Language: English
• Published: 14.03.2024
• Subjects: CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE; ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR; ELECTRICITY; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PRINTED CIRCUITS; TRANSPORTING

A soft and stretchable microelectrode array (sMEA) including a first circuit board having a first though hole; a second circuit board having a second through hole; a microelectrode array including a plurality of microelectrodes embedded in an elastomeric substrate, wherein the microelectrode array is disposed between the first and second printed circuit boards, and includes an exposed portion corresponding the first and second through holes; a plurality of contact pads formed on a top or bottom surface of the first printed circuit board and electrically connected to the plurality of microelectrodes; and a culture well mounted on the first printed circuit board and encompassing the first through hole. Further, the exposed portion of the microelectrode array includes a 3D pocket lined with stretched microelectrodes for electrically stimulating and recording signals from an organoid placed in the 3D pocket.