HDAC INHIBITORS

The present disclosure is directed to chromane compounds, chromane compounds demonstrating HDAC inhibition, and pharmaceutical compositions thereof. Additional embodiments include methods of using the chromane compounds. For example, the disclosure includes methods of inhibiting histone acetylation...

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Main Authors Kristufek, Tyler, Huryn, Donna M, Panda, Jagannath, Terrab, Leila, Sozer, Uygar, Liang, Mary, Chauhan, Shikha Singh, Crocker, Desirae Lynn, Wipf, Peter, Joyasawal, Sipak, Topacio, Andrea, Thornton, Alyssa, LaPorte, Matthew G, Houghton, Michael James, Iyer, Prema, Maskrey, Taber Sarah
Format Patent
LanguageEnglish
Published 15.02.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present disclosure is directed to chromane compounds, chromane compounds demonstrating HDAC inhibition, and pharmaceutical compositions thereof. Additional embodiments include methods of using the chromane compounds. For example, the disclosure includes methods of inhibiting histone acetylation in a cell, comprising contacting the cell with a chromane compound of the disclosure. Additional embodiments include methods of treating a disease capable of treatment by inhibition of histone acetylation in a patient in need thereof, comprising administering a chromane compound of the disclosure.
Bibliography:Application Number: US202118039941