PRODRUGS OF CYTOTOXIC ACTIVE AGENTS HAVING ENZYMATICALLY CLEAVABLE GROUPS

The invention relates to novel prodrugs or conjugates of the general formula (Ia)in which cytotoxic drugs, for example kinesin spindle protein inhibitors, are masked with legumain-cleavable groups and hence release the drug, and to the use of these prodrugs or conjugates for treatment and/or prevent...

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Main Authors SOMMER, Anette, LERCHEN, Hans-Georg, MARX, Leo, JOHANNES, Sarah Anna Liesa, DIETZ, Lisa, REBSTOCK, Anne-Sophie, TERJUNG, Carsten, GREVEN, Simone, STELTE-LUDWIG, Beatrix, MAHLERT, Christoph, BERNDT, Sandra
Format Patent
LanguageEnglish
Published 08.02.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to novel prodrugs or conjugates of the general formula (Ia)in which cytotoxic drugs, for example kinesin spindle protein inhibitors, are masked with legumain-cleavable groups and hence release the drug, and to the use of these prodrugs or conjugates for treatment and/or prevention of diseases, and to the use of these prodrugs or conjugates for production of medicaments for treatment and/or prevention of diseases, especially of hyperproliferative and/or angiogenic disorders, for example cancers.
Bibliography:Application Number: US202318175265