METHOD OF ISOLATING AND MEASURING DESMOSINE AND ISODESMOSINE IN ELASTIN

A method of isolating desmosine and isodesmosine in elastin includes hydrolyzing a sample of elastin and separating the desmosine and isodesmosine within a high-performance liquid chromatography (HPLC) column. A mobile phase gradient includes a first solvent solution of MSA (methane sulfonic acid) a...

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Bibliographic Details
Main Author ROMEO, David
Format Patent
LanguageEnglish
Published 25.01.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
TESTING
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Summary:A method of isolating desmosine and isodesmosine in elastin includes hydrolyzing a sample of elastin and separating the desmosine and isodesmosine within a high-performance liquid chromatography (HPLC) column. A mobile phase gradient includes a first solvent solution of MSA (methane sulfonic acid) and HSA (sodium hexanesulfonate) and a second solvent solution of formic acid in Acetonitrile. The desmosine and isodesmosine may be measured as eluents based upon a HPLC chromatogram.
Bibliography:Application Number: US202318330397