3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS

The invention relates to a method of treating a MEK-associated tumor by administering to a subject in need thereof a therapeutically effective amount of a solid form 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

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Bibliographic Details
Main Authors FULTON, Jennifer Lynn, DAHLKE, Joshua Ryan, CLARK, Wesley Dewitt, MORENO, David Austin, KNAPP, Ellen Margaret, DOERNER BARBOUR, Patrick Michael, ALLEN, Shelley, COWDREY, Connor James, BLAKE, James Francis, O'LEARY, Jacob Matthew, REN, Li, KELLUM, Alex Andrew, BLANCHE, Sydney Taylor, WITKOS, Faith Elizabeth, BOYS, Mark Laurence
Format Patent
LanguageEnglish
Published 04.01.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a method of treating a MEK-associated tumor by administering to a subject in need thereof a therapeutically effective amount of a solid form 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.
Bibliography:Application Number: US202318469132