PROCESS OF PREPARING A PD-1/PD-L1 INHIBITOR

The present invention relates to processes of preparing PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3′-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, or salts thereof, related synthetic intermedia...

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Main Authors Lin, Qiyan, Su, Naijing, Jia, Zhongjiang, Liu, Pingli, Zhou, Jiacheng, Li, Yi, Shi, Chongsheng Eric, Chen, Shili, Pan, Yongchun, Martin, Timothy, Wu, Yongzhong, Shen, Bo, Xia, Michael
Format Patent
LanguageEnglish
Published 21.12.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to processes of preparing PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3′-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, or salts thereof, related synthetic intermediates, and salts of the intermediates, where the PD-1/PD-L1 inhibitor is useful in the treatment of various diseases including infectious diseases and cancer.
Bibliography:Application Number: US202318240805