MODIFIED HTERT PROMOTER FOR REGULATING CANCER CELL-SPECIFIC GENE EXPRESSION AND ANTI-TUMOR ADENOVIRUS CONTAINING SAME
The present invention relates to a modified hTERT promoter for regulating cancer cell-specific gene expression and an oncolytic adenovirus including the same. The modified hTERT promoter of the present invention increases the cancer-specific transcriptional activity of a target gene compared to the...
Saved in:
Main Authors | , , |
---|---|
Format | Patent |
Language | English |
Published |
21.12.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The present invention relates to a modified hTERT promoter for regulating cancer cell-specific gene expression and an oncolytic adenovirus including the same. The modified hTERT promoter of the present invention increases the cancer-specific transcriptional activity of a target gene compared to the case where a wild-type hTERT promoter is used, and when the modified hTERT promoter is used for an oncolytic adenovirus, the tumor-killing effect is excellent compared to the case where an adenovirus is prepared using the wild-type hTERT promoter. |
---|---|
Bibliography: | Application Number: US202118037487 |