7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1

Compounds of the following formula (I); or the pharmaceutically acceptable salts thereof, are inhibitors of haematopoietic progenitor kinase 1 (HPK1) useful in the treatment of diseases or disorders associated with HPK1. Also disclosed herein are uses of these compounds in the potential treatment or...

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Main Authors Liu, Ping, Methot, Joey L, Vara, Brandon A, Chen, Joanna L, Kawamura, Shuhei, Pasternak, Alexander, Candito, David A, Donofrio, Anthony, Nair, Anilkumar G, Fuller, Peter H, Lim, Jongwon, Fradera, Xavier, Yu, Elsie C, Li, Bing
Format Patent
LanguageEnglish
Published 14.12.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Compounds of the following formula (I); or the pharmaceutically acceptable salts thereof, are inhibitors of haematopoietic progenitor kinase 1 (HPK1) useful in the treatment of diseases or disorders associated with HPK1. Also disclosed herein are uses of these compounds in the potential treatment or prevention of an HPK1-associated disease or disorder. Also disclosed herein are compositions comprising one or more of the compounds. Further disclosed herein are uses of these compositions in the potential prevention or treatment of an HPK1-associated disease or disorder.
Bibliography:Application Number: US202118250419