Novel Polysaccharide and Uses Thereof

Provided herein is an E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells containing enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce O25B bioconjugates, wherein said bioconjugates contain O25B linked to a carrier protei...

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Bibliographic Details
Main Authors MALLY, Manuela, KOWARIK, Michael T, HÄUPTLE, Micha A, WETTER, Michael L, KEMMLER, Stefan J, GAMBILLARA, Veronica
Format Patent
LanguageEnglish
Published 16.11.2023
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
PEPTIDES
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:Provided herein is an E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells containing enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce O25B bioconjugates, wherein said bioconjugates contain O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, including O25B and/or bioconjugates containing O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further include one or more additional bioconjugates.
Bibliography:Application Number: US202318305948