Synthetic Implantable Composition with Immunomodulatory Properties

Implantable compositions are based on polymers bearing pendant groups on the polymer backbone functionalized with short chain fatty acid groups, such as one or more of acetate, n-propionate, and n-butyrate by a degradable linkage. Upon a composition being implanted in a subject, such as a human, deg...

Full description

Saved in:
Bibliographic Details
Main Authors Amsden, Brian G, Chen, Fei
Format Patent
LanguageEnglish
Published 09.11.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:Implantable compositions are based on polymers bearing pendant groups on the polymer backbone functionalized with short chain fatty acid groups, such as one or more of acetate, n-propionate, and n-butyrate by a degradable linkage. Upon a composition being implanted in a subject, such as a human, degradation of degradable linkage liberates the short chain fatty acid groups. The liberated short chain fatty acid groups may then participate in biochemical processes in the subject, which may produce a therapeutic benefit such as resolving inflammation, promoting tissue healing, and/or promoting tolerating self-antigens and neoantigens.
Bibliography:Application Number: US202318142878