Bifunctional Proteins Combining Checkpoint Blockade for Targeted Therapy
Provided are bispecific proteins that comprise a binding domain binding cell surface protein and a vascular endothelial growth factor (VEGF) inhibiting domain. Provided also is an antibody-drug conjugate that comprises a therapeutic agent and an antibody or an antigen-binding fragment binding PD-L1...
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Main Authors | , , , |
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Format | Patent |
Language | English |
Published |
12.10.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Provided are bispecific proteins that comprise a binding domain binding cell surface protein and a vascular endothelial growth factor (VEGF) inhibiting domain. Provided also is an antibody-drug conjugate that comprises a therapeutic agent and an antibody or an antigen-binding fragment binding PD-L1 and/or a VEGF inhibiting domain, wherein the therapeutic agent is covalently conjugated to the antibody or the antigen-binding fragment by a linker. |
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Bibliography: | Application Number: US202318214160 |