Polyphenolic Insulin

Insulin complexes are stabilized using a ligand that increases binding interactions between the insulin monomers, and particularly between the B-chains of two adjacent insulin monomers. Particularly preferred ligands are polyphenols, and insulin complexes are typically in the R-state and may therefo...

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Bibliographic Details
Main Author Reddy, Robert R
Format Patent
LanguageEnglish
Published 12.10.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Insulin complexes are stabilized using a ligand that increases binding interactions between the insulin monomers, and particularly between the B-chains of two adjacent insulin monomers. Particularly preferred ligands are polyphenols, and insulin complexes are typically in the R-state and may therefore also include metal cations and a small phenolic compound in a binding site that is distinct from the polyphenol binding site.
Bibliography:Application Number: US202118019576