ROCURONIUM BROMIDE PREFILLED SYRINGE

• Main Authors: Jarmusik, Keith, AbuRmaileh, Ragheb M
• Format: Patent
• Language: English
• Published: 05.10.2023
• Subjects: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Prefilled syringes containing a rocuronium bromide solution, where the prefilled syringes comprise a syringe barrel and a syringe tip comprising cyclic olefin monopolymer ("COP") or cyclic olefin copolymer ("COC"), and having a plunger rod stopper comprising bromobutyl rubber. The syringes can also comprise a luer adapter integral with the syringe tip, where the syringe barrel, syringe tip and luer adapter are a single element comprising COP or COC. The rocuronium bromide solutions include rocuronium bromide, a tonicity agent, one or more buffering agents, and one or more pH adjusters in an aqueous solution having a pH from about 3.8-4.2. The prefilled syringes containing the rocuronium bromide solutions are storage-stable for extended periods of time at a temperature of 2-8° C., have acceptable physical parameters such as glide force and break force, and make safe and robust connections with needles and needleless luer adapter devices ("NLADs").