SELF-ASSEMBLING PEPTIDES, PREPARATION METHODS, SELF-ASSEMBLING PEPTIDE FORMULATIONS AND USE

• Main Authors: Gao, Weiwei, Bai, Huan, Zhang, Zaiqing, Gao, Lichang, Feng, Jinhui, Zhang, Xudong, Liu, Changfeng, Zhao, Lili, Liu, Yuanxue, Zhao, Chengru, Yan, Yongli, Li, Fangmin, Wang, Pin, Guo, Junying, Zhang, Chunxia, Zhang, Shang
• Format: Patent
• Language: English
• Published: 05.10.2023
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC CHEMISTRY; PEPTIDES

Provided is a self-assembling peptide, a preparation method, the self-assembling peptide formulations and use, and it is related to the field of biotechnology. The self-assembling peptide provided by the present disclosure has a general formula as shown in AC-Pro-X1-X3-X2-X3-X1-X3-X2-Pro-amide. Through experiments, the inventors of the present disclosure found that the self-assembling peptide provided by the present disclosure, because solubility is high and difficulty of synthesis and purification is less compared with a traditional self-assembling peptide, is more feasible for industrial production, and even cheaper to produce. In mass synthesis and purification, the number of purification decreases, the single purification amount increases, the purity of a crude peptide can reach 90% or more, and the cost is greatly reduced.