Bispecific Anti-PSMA x Anti-CD28 Antibodies and Uses Thereof

The present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD28, and a second antigen-binding molecule that specifically binds human PSMA. In certain embodiments, the bispecific antigen- binding molecules of the present...

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Main Authors Haber, Lauric, Hermann, Aynur, Yancopoulos, George D, Murphy, Andrew J, Ullman, Erica, Smith, Eric, Waite, Janelle, Skokos, Dimitris
Format Patent
LanguageEnglish
Published 28.09.2023
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD28, and a second antigen-binding molecule that specifically binds human PSMA. In certain embodiments, the bispecific antigen- binding molecules of the present invention are capable of inhibiting the growth of tumors expressing PSMA, such as prostate tumors. The antibodies and bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an up-regulated or induced targeted immune response is desired and/or therapeutically beneficial.
Bibliography:Application Number: US202218077139