PYRIDOPYRIMIDINONE DERIVATIVES AS AHR ANTAGONISTS

The present disclosure relates to compounds of formula (Ia) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in par...

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Main Authors GUO, Tianlin, BUREAU, Patrick, BOS, Maxence, BLOIS, Anna, BRIGGS, Timothy, BONEPALLY, Karunakar Reddy, BARONE, Francesca, BARTOLOZZI, Alessandra, BUCKBINDER, Leonard, PROUDFOOT, John Robert, MANCUSO, John, LANTER, Bernard, TAYLOR, Steven John
Format Patent
LanguageEnglish
Published 21.09.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to compounds of formula (Ia) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling. These compounds may also be useful in treating cancer when administered in combination with at least one additional therapy.
Bibliography:Application Number: US202017756243