INHIBITORS OF COMPLEMENT FACTOR C3 AND THEIR MEDICAL USES

Compstatin analogues having improved physicochemical properties, such as increased stability and/or solubility as compared to the 13 amino acid compstatin peptide are described, in particular compstatin analogues that additionally possess useful binding and complement-inhibiting activity. These anal...

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Bibliographic Details
Main Authors LETH, Rasmus, SHELTON, Anne Pernille Tofteng, MUNCH, Henrik Fischer
Format Patent
LanguageEnglish
Published 14.09.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compstatin analogues having improved physicochemical properties, such as increased stability and/or solubility as compared to the 13 amino acid compstatin peptide are described, in particular compstatin analogues that additionally possess useful binding and complement-inhibiting activity. These analogues have an alkylene bridge between sulphur atoms of cysteine residues and include variants with an isoleucine residue at position 3 in place of the wild type valine residue, which provides compstatin peptides with improved binding and complement-inhibiting activity and also enables the introduction of other modifications, for example modifications that are capable of increasing stability, such as the introduction of lysine or serine at position 11.
Bibliography:Application Number: US202118016490