Localizing and Imaging Magnetic Nanoparticles Assisted by Electron Paramagnetic Resonance

An MNP machine provides a magnetic bias field to a sample space; drive coils bracketing the sample space; pickup coils coupled through amplifiers to a computer; and a radio frequency (RF) stimulus coil driven at an electron paramagnetic resonance (EPR) frequency of MNPs in the bias field. The comput...

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Bibliographic Details
Main Author Weaver, John B
Format Patent
LanguageEnglish
Published 07.09.2023
Subjects
DIAGNOSIS
ELECTROTHERAPY
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
MAGNETOTHERAPY
MEASURING
MEASURING ELECTRIC VARIABLES
MEASURING MAGNETIC VARIABLES
MEDICAL OR VETERINARY SCIENCE
PHYSICS
RADIATION THERAPY
SURGERY
TESTING
ULTRASOUND THERAPY
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Summary:An MNP machine provides a magnetic bias field to a sample space; drive coils bracketing the sample space; pickup coils coupled through amplifiers to a computer; and a radio frequency (RF) stimulus coil driven at an electron paramagnetic resonance (EPR) frequency of MNPs in the bias field. The computer is configured to provide a MNP Brownian motion spectrum from the signals or magnetic particle images. A method of imaging MNP concentrations in a subject includes applying a magnetic bias field having a gradient; applying RF at an EPR frequency of the MNPs in the magnetic bias field; sweeping either magnetic bias field strength or radio frequency to sweep a surface of resonance through the subject; observing EPR resonances of the MNPs; rotating the magnetic bias field relative to the subject; repeating sweeping the surface of resonance through the subject; and reconstructing a three-dimensional model of MNP concentrations of the subject.
Bibliography:Application Number: US202318116742