COMPOSITIONS FOR PREVENTING OR TREATING DIABETIC SKIN DISEASE COMPRISING EXOSOME-DERIVED FROM THROMBIN-TREATED STEM CELL

• Main Authors: CHANG, Yun Sil, PARK, Won Soon, SUNG, Dong Kyung
• Format: Patent
• Language: English
• Published: 17.08.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to: a pharmaceutical composition which is for preventing or treating diabetic skin disease, and comprises, as an active ingredient, an exosome derived from a thrombin-treated stem cell; a pharmaceutical formulation containing said composition; and a method for producing same. In the present invention, an exosome isolated from a thrombin-treated stem cell was found to have an excellent effect on the recovery of diabetic animal models from diabetic dermatopathy. In addition, since exosome-based therapeutics are cell-free formulations and thus do not include DNA, such therapeutics have a low risk of cancer and are free of cell surface antigens. Accordingly, exosome-based therapeutics do not have the issue of transplant rejection and are thus safe. Accordingly, the exosome derived from a thrombin-treated stem cell according to the present invention can be developed as a therapeutic agent for various intractable chronic skin diseases that can be caused by diabetes.