NUCLEIC ACID LIPID PARTICLE VACCINE

• Main Authors: YAMAYOSHI, Seiya, NIWA, Takako, ONODERA, Yoshikuni, TAKESHITA, Fumihiko, IMAI, Masaki, OKA, Tatsuya, KOIZUMI, Makoto, ISHII, Ken, KAWAOKA, Yoshihiro, JONAI, Nao, SUZUKI, Takashi, TOZUKA, Miyuki, NAKAMURA, Kensuke, NAMBA, Eiko, KOBIYAMA, Kouji
• Format: Patent
• Language: English
• Published: 10.08.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a vaccine for preventing and/or treating infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).The present invention relates to a lipid particle encapsulating a nucleic acid molecule capable of expressing the S protein and/or a fragment thereof of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), wherein the lipid comprises a cationic lipid represented by general formula (Ia) or a pharmaceutically acceptable salt thereof:wherein R1 and R2 each independently represent a C1-C3 alkyl group;L1 represents a C17-C19 alkenyl group which may have one or a plurality of C2-C4 alkanoyloxy groups;L2 represents a C10-C19 alkyl group which may have one or a plurality of C2-C4 alkanoyloxy groups or a C10-C19 alkenyl group which may have one or a plurality of C2-C4 alkanoyloxy groups; andp is 3 or 4.