Chemically Coupled Transporter for Low-Hydrophobicity Bioactive Drugs into the Central Nervous System

The present disclosure provides a compound comprising a modified tetracycline derivative, covalently coupled through a linker defined by the generic formula XZX to a low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases, particularly a compound wherein the modified tet...

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Main Authors Luong, Martin, Chaves, Analía Silvina, Varela, Oscar José, Socías, Sergio Benjamin, Kolender, Adriana Andrea, Pingitore, Esteban Vera, Pernicone, Agustín Osvaldo, Tomas Grau, Rodrigo Hernán, González Lizárraga, Maria Florencia, Chehín, Rosana Nieves, Ávila, Cesar Luis, Ploper, Diego, Manzano, Verónica Elena
Format Patent
LanguageEnglish
Published 13.07.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure provides a compound comprising a modified tetracycline derivative, covalently coupled through a linker defined by the generic formula XZX to a low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases, particularly a compound wherein the modified tetracycline derivative is a chemically modified doxycycline derivative and the low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases is dopamine. The disclosure also provides a process for preparing such compound, as well as methods for treating a neurodegenerative disease comprising administering said compound.
Bibliography:Application Number: US202318121318