SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION

The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising...

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Main Authors KOSEMUND, Dirk, STÖCKIGT, Detlef, HERBERT, Simon Anthony, OFFRINGA, Rienk, MEIER, Robin Michael, WERBECK, Nicolas, WORTMANN, Lars, NGUYEN, Thi Thanh Uyen, BÖMER, Ulf, LECHNER, Christian, KOBER, Christina, PETERSEN, Kirstin, SCHMEES, Norbert, GREES, Mareike, KIRCHOFF, Dennis, KERSCHGENS, Isabel Patrizia
Format Patent
LanguageEnglish
Published 29.06.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
Bibliography:Application Number: US202218072490