NOVEL LIPIDS AND NANOPARTICLE COMPOSITIONS THEREOF

Provided herein are lipids having the Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R1′, R2, R2′, R3, R3′, R4, R4′, R5, and R5′, are as defined herein. Also provided herein are lipid nano article (LNP) compositions comprising lipid having the Formula (I) and a capsid-free,...

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Bibliographic Details
Main Authors Nolting, Birte, Stanton, Matthew G
Format Patent
LanguageEnglish
Published 15.06.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided herein are lipids having the Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R1′, R2, R2′, R3, R3′, R4, R4′, R5, and R5′, are as defined herein. Also provided herein are lipid nano article (LNP) compositions comprising lipid having the Formula (I) and a capsid-free, non-viral vector (e.g., ceDNA). In one aspect, these LNPs can be used to deliver a capsid-free, non-viral DNA vector to a target site of interest (e.g., cell, tissue, organ, and the like).
Bibliography:Application Number: US202117925404