CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS

Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molec...

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Bibliographic Details
Main Authors ZHAO, Robert Yongxin, LI, Wenjun, GAI, Shun, ZHUO, Xiaotao, ZHENG, Jun, HUANG, Yuanyuan, JIA, Junxiang, YANG, Qingliang, ZHANG, Xiuzheng, CAI, Xiang, ZHOU, Xiaomai, GUO, Huihui, XU, Yifang, LEI, Jun, TONG, Qianqian, ZHAO, Linyao, XIE, Hongsheng, YE, Hangbo, BAI, Lu, CAO, Mingjun
Format Patent
LanguageEnglish
Published 01.06.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
Bibliography:Application Number: US202318156709