ADENOSINE RECEPTOR ANTAGONIST COMPOUNDS

The present disclosure provides adenosine receptor (e.g., A2A and/or A1 receptor) antagonist compounds and compositions including said compounds. The present disclosure also provides methods of using said compounds and compositions for modulating (e.g., inhibiting or antagonizing) A2A and/or A1 rece...

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Main Authors KWON, Sung-Wook, KIM, Jeong-Geun, JUNG, Ju-Young, LEE, Soo-Jin, KIM, Jeong-Ah, BAN, Jun-Su, MOON, An-Na, PARK, Sun-Young, LEE, Yoon-Suk, KIM, Kyung-Sun, SONG, Dong-Keun
Format Patent
LanguageEnglish
Published 25.05.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure provides adenosine receptor (e.g., A2A and/or A1 receptor) antagonist compounds and compositions including said compounds. The present disclosure also provides methods of using said compounds and compositions for modulating (e.g., inhibiting or antagonizing) A2A and/or A1 receptor in a biological system. The compounds and compositions find use in various therapeutic applications including the treatment of cancer and in immuno-oncology. The compounds and compositions find use in various therapeutic applications including the treatment of central nervous system or neurodegenerative diseases, such as Parkinson's disease.
Bibliography:Application Number: US202017777881