MODIFIED MICROORGANISM AND METHOD FOR THE IMPROVED PRODUCTION OF ECTOINE

The present invention relates to a microorganism genetically modified for production of ectoine, wherein said microorganism comprises the following modifications: expression of a heterologous gene ectA encoding a diaminobutyric acid acetyltransferase having at least 90% similarity with SEQ ID NO: 1,...

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Bibliographic Details
Main Authors DUMON-SEIGNOVERT, Laurence, RAYNAUD, Céline, DESFOUGERES, Thomas
Format Patent
LanguageEnglish
Published 18.05.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to a microorganism genetically modified for production of ectoine, wherein said microorganism comprises the following modifications: expression of a heterologous gene ectA encoding a diaminobutyric acid acetyltransferase having at least 90% similarity with SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or SEQ ID NO: 5, a heterologous gene ectB encoding a diaminobutyric acid aminotransferase having at least 90% similarity with SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9 or SEQ ID NO: 10, a heterologous gene ectC encoding an ectoine synthase having at least 90% similarity with SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14 or SEQ ID NO: 15 and deletion of pykA and pykF genes. The present invention also relates to a method for the production of ectoine using said microorganism.
Bibliography:Application Number: US202117797907