MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for t...

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Bibliographic Details
Main Authors MacCleod, Calum, Roberts, Tucker Curran, Ly, Cuong Q, Koehler, Michael F. T, Hu, Huiyong, Chen, Yongsheng, Yu, Zhiyong, Hanan, Emily J, Crawford, James John, Blench, Toby, Paraselli, Prasuna, Smith, Peter Andrew, Winship, Paul Colin Michael, Higuchi, Robert I, Schwarz, Jacob Bradley
Format Patent
LanguageEnglish
Published 04.05.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
Bibliography:Application Number: US202218047624