RECOMBINANT PEPTIDES THAT BIND TO A TUMOUR-SPECIFIC ANTIBODY FOR BREAST CANCER AND USE

• Main Authors: VAZ, Emilia Rezende, RIBIERO, Matheus Alves, MOTA, Sara Teixeira Soares, FILHO, Luiz Ricardo Goulart, ARÁUJO, Thaise Goncalves De, VECCHI, Lara, ZÓIA, Mariana Alves Pereira, ALVES, Douglas Alexsander, MAIA, Yara Cristina de Paiva, ARAUJO, Galber Rodrigues
• Format: Patent
• Language: English
• Published: 27.04.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The present invention refers to the use of synthetic peptides built from the selection of peptides available on the surface of filamentous phages and that bind to the FabC4 antibody fragment with clinical relevance in the diagnosis of Breast Cancer (BC) and in the prognosis of Triple-Negative Breast Cancer (TNBC). The peptides were specific to tumor proteins and could be potentially used in immunodiagnostic tests, formulations coupled to fluorescent or radioactive particles for diagnostic imaging, therapeutic drug carriers, and in immunogenic compositions for BC management. The technology used for peptide selection was the peptide expression system on the surface of filamentous bacteriophage. The strategy used was the selection of binding peptides of tumor proteins present in serum from TNBC patients.