CONTINUOUS-FLOW SYNTHESIS METHOD OF 13C-UREA

A continuous-flow synthesis method of 13C-urea, including: (S1) mixing sulphur and a methanol solution containing NH3 in a feed kettle to obtain a slurry; or mixing ammonia gas, sulphur and methanol in a feed kettle to obtain a slurry; (S2) feeding the slurry into a mixing unit; and feeding 13CO int...

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Bibliographic Details
Main Authors HAN, Quansheng, DAI, Desheng, LIAO, Jingyuan, QING, Jing, CHEN, Kai, YOU, Hengzhi, JIA, Xuelei, LI, Guowei
Format Patent
LanguageEnglish
Published 20.04.2023
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:A continuous-flow synthesis method of 13C-urea, including: (S1) mixing sulphur and a methanol solution containing NH3 in a feed kettle to obtain a slurry; or mixing ammonia gas, sulphur and methanol in a feed kettle to obtain a slurry; (S2) feeding the slurry into a mixing unit; and feeding 13CO into the mixing unit to obtain a three-phase mixture; (S3) mixing the three-phase mixture in the mixing unit evenly; feeding the three-phase mixture into a continuous-flow reactor for reaction to obtain a reaction product; and (S4) feeding the reaction product into a gas-liquid separator for gas-liquid separation, and collecting a liquid phase as a crude product solution; and subjecting the liquid phase to purification to obtain the 13C-urea.
Bibliography:Application Number: US202218067293