COMPOSITIONS AND METHODS FOR TREATING CANCER

The present disclosure relates to compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating glioblastoma and other EGFR-mediated cancers, such as those that have been determined to have al...

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Bibliographic Details
Main Authors Tsang, Jonathan, Jung, Michael E, Kim, Gyudong, Nathanson, David A, Urner, Lorenz, Clark, Peter M, Cloughesy, Timothy F
Format Patent
LanguageEnglish
Published 13.04.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present disclosure relates to compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating glioblastoma and other EGFR-mediated cancers, such as those that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.
Bibliography:Application Number: US202217853573