TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS

Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

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Bibliographic Details
Main Authors Hoang, Gia, Li, Gencheng, Li, Zhenwu, McAtee, Rory, Policarpo, Rocco, Yao, Wenqing, HU, Bin, Mukai, Ken, Susick, Robert, Wang, Xiaozhao, YU, Zhiyong, Roach, Jeremy
Format Patent
LanguageEnglish
Published 13.04.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.
Bibliography:Application Number: US202217812310