Lu-177 RADIOCHEMISTRY SYSTEM AND METHOD

• Main Authors: OELSNER, Stephen M, WIGGINS, Bryan Blake, HUNTER, Gary, GLENN, David J, POLICKE, Timothy A
• Format: Patent
• Language: English
• Published: 13.04.2023
• Subjects: CONVERSION OF CHEMICAL ELEMENTS; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; NUCLEAR ENGINEERING; NUCLEAR PHYSICS; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; RADIOACTIVE SOURCES; TESTING

A method of making Lu-177 involving dissolving enriched Yb2O3, loading dissolved enriched Yb2O3 on a first guard column containing resin prepared from (2-ethyl-1-hexyl)phosphonic acid mono(2-ethyl-1-hexyl)ester (HEH[EHP]), passing a first separation of a stream exiting from first guard column through a first resin cartridge containing dipentyl pentylphosphonate, collecting Lu-177 onto a first collection column having resin containing tetraoctyl diglycolamide (DGA), loading an exiting stream from first collection column on a second guard column containing resin prepared from (2-ethyl-1-hexyl)phosphonic acid mono(2-ethyl-1-hexyl)ester (HEH[EHP]); passing a first separation of a stream exiting from second guard column through a second resin cartridge containing dipentyl pentylphosphonate; collecting Lu-177 onto a second collection column having resin containing DGA; passing a second separation of a stream exiting from second guard column through a third resin cartridge containing dipentyl pentylphosphonate; and collecting Lu-177 having passed through the third resin cartridge onto a third collection column having resin containing DGA.