NOVEL PROTEIN PORES

The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional...

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Main Authors Wallace, Elizabeth Jayne, Kilgour, John Joseph, Remaut, Han, Singh, Pratik Raj, Hambley, Richard George, Van Gerven, Nani, Van Der Verren, Sander Egbert, Jayasinghe, Lakmal Nishantha, Jordan, Michael Robert
Format Patent
LanguageEnglish
Published 16.03.2023
Subjects
CHEMISTRY
MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES
METALLURGY
NANOTECHNOLOGY
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
TRANSPORTING
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Summary:The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
Bibliography:Application Number: US202217933061