METHOD FOR REDUCING SKIN SENSITIZATION OF AN ASENAPINE-CONTAINING PATCH

A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising:using an adhesive agent for preparing the adhesive agent layer, the adhesive agent containing free asenapine in a range of 2 to 5% by mass, styrene-...

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Bibliographic Details
Main Authors TAMURA, Ryoma, TAKAGI, Yuka, KUROKAWA, Takao, MICHINAKA, Yasunari, ISHIDA, Kazuya
Format Patent
LanguageEnglish
Published 02.02.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising:using an adhesive agent for preparing the adhesive agent layer, the adhesive agent containing free asenapine in a range of 2 to 5% by mass, styrene-isoprene-styrene block copolymer (SIS) in a range of 7 to 18% by mass, polyisobutylene (PIB) in a range of 0.5 to 10% by mass, alicyclic saturated hydrocarbon resin in a range of 30 to 70% by mass, and liquid paraffin in a range of 5 to 10% by mass, relative to a total amount of the adhesive agent; andpreparing the asenapine-containing patch whose average cumulative amount of skin permeation of asenapine (24 hours) after applying the asenapine-containing patch to skin of a dorsal scapular region of a 5-week-old Hartley white female guinea pig and holding the asenapine-containing patch with an occlusive dressing for 24 hours is in a range of 90 to 300 μg/cm2 in terms of free form.
Bibliography:Application Number: US202117381294