PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions fav...

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Main Authors Xiong, Zhaoming, Bogdan, Andrew, Farney, Elliot P, Zhang, Qingwei, Wang, Xueqing, Economou, Christos, O'Connor, Matthew J, Shiroodi, Reza, Zhao, Hongyu, Abbott, Jason R, Baumgartner, Christina, Frost, Jennifer M, Halvorsen, Geoff T, Kym, Philip R
Format Patent
LanguageEnglish
Published 19.01.2023
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Summary:Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.
Bibliography:Application Number: US202217807292