IMMUNOCYTOKINE COMPRISING HETERODYMERIC PROTEIN COMPLEX BASED ON IL-15/IL-15RA

The present invention relates to an immunocytokine comprising an heterodimeric protein complex based on IL-15/IL-15Rα, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease. The present invention further relates to an immunocytokin...

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Main Authors GORDEEV, Aleksandr Andreevich, KONONOV, Aleksey Vladimirovich, SHMAKOVA, Aleksandra Pavlovna, ULITIN, Andrei Borisovich, EVDOKIMOV, Stanislav Rudolfovich, MITROSHIN, Ivan Vladimirovich, MOROZOV, Dmitry Valentinovich, VINOGRADOVA, Elena Vladimirovna, AGEEV, Sergei Andreevich
Format Patent
LanguageEnglish
Published 12.01.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to an immunocytokine comprising an heterodimeric protein complex based on IL-15/IL-15Rα, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease. The present invention further relates to an immunocytokine comprising a heterodimeric protein complex based on an IL-15/IL-15Rα and an immunomodulatory antibody, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease.
Bibliography:Application Number: US202017761838