TGR5 MODULATORS AND METHODS OF USE THEREOF

The application relates to compounds of formula A:or a salt, solvate, ester, tautomer, amino acide conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, car...

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Bibliographic Details
Main Authors SEEDORF, Klaus, PELLICCIARI, Roberto, PERRON-SIERRA, Francoise, GIOIELLO, Antimo, MACCHIARULO, Antonio
Format Patent
LanguageEnglish
Published 01.12.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:The application relates to compounds of formula A:or a salt, solvate, ester, tautomer, amino acide conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
Bibliography:Application Number: US202217720938