LTBP COMPLEX-SPECIFIC INHIBITORS OF TGFb AND USES THEREOF

Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering f...

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Main Authors Wawersik, Stefan, Stein, Caitlin, Fogel, Adam, Datta, Abhishek, McCreary, Julia, Schurpf, Thomas, Streich, JR., Frederick, Salotto, Matthew, Littlefield, Christopher, Jackson, Justin W, Coricor, George
Format Patent
LanguageEnglish
Published 17.11.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof are also provided.
Bibliography:Application Number: US202217746325