BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TSLP

The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of thymic stromal lymphopoietin...

Full description

Saved in:
Bibliographic Details
Main Authors WATCHAM, Sophie, SVENSSON, Tor, HIDESTAL, Lotta, SKYNNER, Michael, NARJES, Frank, CHEN, Liuhong, ZLATOIDSKY, Pavol
Format Patent
LanguageEnglish
Published 17.11.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of thymic stromal lymphopoietin (TSLP). The invention also includes pharmaceutical compositions comprising said peptide ligands and to the use of said peptide ligands in preventing, suppressing or treating a disease or disorder mediated by TSLP.
Bibliography:Application Number: US202117223244