DEVICE AND METHODS FOR TISSUE MOLECULAR PROFILING USING ELECTROPORATION BASED MOLECULAR EXTRACTION

Methods and devices obtain cellular-component, e.g., proteins, RNA, DNA, metabolites, and combinations of these, from a solid tissue in-vivo using electroporation, and subsequently profile such tissue either inside or outside the subject's body. A method for determining if a solid tissue of a s...

Full description

Saved in:
Bibliographic Details
Main Authors YAKHINI, Zohar, GOLBERG, Alexander, SHEVIRYOV, Julia
Format Patent
LanguageEnglish
Published 17.11.2022
Subjects
DIAGNOSIS
ELECTROTHERAPY
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MAGNETOTHERAPY
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
RADIATION THERAPY
SURGERY
TESTING
ULTRASOUND THERAPY
Online AccessGet full text

Cover

More Information
Summary:Methods and devices obtain cellular-component, e.g., proteins, RNA, DNA, metabolites, and combinations of these, from a solid tissue in-vivo using electroporation, and subsequently profile such tissue either inside or outside the subject's body. A method for determining if a solid tissue of a subject includes a benign or malignant tumor, or if a space occupying lesion (SOL) within the solid tissue is malignant or benign, includes placing at least one electroporation-electrode within the solid tissue, or within the SOL or in proximity thereto; applying pulsed electric field (PEF) via the at least one electroporation-electrode to thereby induce permeabilization of cells of the solid tissue or the SOL, and consequently release of at least one cellular-component therefrom to an extracellular matrix between and surrounding the cells; extracting the at least one cellular-component from the extracellular matrix.
Bibliography:Application Number: US202017628148