GENE EXPRESSION SIGNATURE OF ENDOMETRIAL SAMPLES FROM WOMEN WITH AND WITHOUT ENDOMETRIOSIS

The present invention relates to the gene signature of the endometrium which may serve as a non-surgical diagnostic method for endometriosis. The signature includes five genes according to the claimed invention which are downregulated in endometrium and endometriotic lesions of patients with endomet...

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Bibliographic Details
Main Authors STEPANIAN, Assia Arnoldovna, BUZDIN, Anton Aleksandrovich, NIKITIN, Daniil Mikhailovich, ADAMYAN, Leila Vladimirovna, SOROKIN, Maksim Igorevich, SUNTSOVA, Maria Vladimirovna, GARAZHA (AZNAUROVA), Yana Borisovna, GARAZHA, Andrew Vladimirovich
Format Patent
LanguageEnglish
Published 10.11.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to the gene signature of the endometrium which may serve as a non-surgical diagnostic method for endometriosis. The signature includes five genes according to the claimed invention which are downregulated in endometrium and endometriotic lesions of patients with endometriosis, selected after comparison to the endometrium of women without endometriosis. This gene signature demonstrated a capacity of nearly perfect separation of all 52 analyzed tissue samples of patients with endometriosis (both their endometrial samples and endometriosis lesions) from 14 tissue samples of both living and cadaveric patients without endometriosis (AUC=0.982, Matthews correlation coefficient MCC=0.832).
Bibliography:Application Number: US202217739526