CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS

The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

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Bibliographic Details
Main Authors LI, Wenjun, GAI, Shun, GUO, Zhixiang, HUANG, Yuanyuan, YANG, Yanlei, YE, Zhichang, ZHU, Haifeng, JIA, Junxiang, YANG, Qingliang, ZHOU, Xiaomai, GUO, Huihui, XU, Yifang, LI, Chen, YANG, Chengyu, GAO, Shuihong, CAO, Minjun, ZHAO, Yongxin Robert, WANG, Chunyan, TONG, Qianqian, ZHAO, Linyao, XIE, Hongsheng, YE, Hangbo, BAI, Lu
Format Patent
LanguageEnglish
Published 06.10.2022
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
Bibliography:Application Number: US202217835395