DRUG-POLYMER AMORPHOUS SOLID DISPERSIONS USING LINEAR POLY(ACRYLIC ACID) POLYMERS
An amorphous solid dispersion includes a linear poly(acrylic acid) and an active pharmaceutical ingredient. The linear poly(acrylic acid) used to form the amorphous solid dispersion has a Brookfield viscosity of at least 100 cP at 25° C. A method of forming such an amorphous solid dispersion of an a...
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Main Authors | , , , , , , , , , |
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Format | Patent |
Language | English |
Published |
29.09.2022
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Subjects | |
Online Access | Get full text |
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Summary: | An amorphous solid dispersion includes a linear poly(acrylic acid) and an active pharmaceutical ingredient. The linear poly(acrylic acid) used to form the amorphous solid dispersion has a Brookfield viscosity of at least 100 cP at 25° C. A method of forming such an amorphous solid dispersion of an active pharmaceutical ingredient includes forming a liquid dispersion of a linear poly(acrylic acid), an active pharmaceutical ingredient, and a solvent system, the linear poly(acrylic acid) having a Brookfield viscosity at 25° C. of at least 100 cP and evaporating the solvent system from the liquid dispersion to form an amorphous solid dispersion. |
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Bibliography: | Application Number: US202017635815 |