CONTINUOUS METHOD FOR NANO-EMULSIFICATION BY CONCENTRATION PHASE INVERSION

A continuous process for nano-emulsification that is performed by concentration phase inversion in a microfluidic reactor, including the following steps: (a) injection of an aqueous phase into a first microchannel, the first microchannel opening onto a formulation chamber, (b) injection, into a seco...

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Main Authors ROGER, Emilie, GIMEL, Jean-Christophe, BASTIAT, Guillaume, CALVIGNAC, Brice, MATHA, Kévin, LEFEBVRE, Guillaume, ROLLEY, Nicolas, FOUCHET, Florian
Format Patent
LanguageEnglish
Published 01.09.2022
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A continuous process for nano-emulsification that is performed by concentration phase inversion in a microfluidic reactor, including the following steps: (a) injection of an aqueous phase into a first microchannel, the first microchannel opening onto a formulation chamber, (b) injection, into a second microchannel, of a fatty phase including one or more fatty substances immiscible in the aqueous phase, and one or more surfactants, the second microchannel opening into the formulation chamber, then (c) mixing of the aqueous phase and the fatty phase in the formulation chamber, then (d) recovering, at the output of the formulation chamber, a suspension including lipid nanocapsules. Also, the lipid nanocapsules obtainable by the process, and the use of the lipid nanocapsules as nanovectors for pharmacologically active ingredients.
Bibliography:Application Number: US202017626914