AUTOMATED BIOMASS-BASED PERFUSION CONTROL IN THE MANUFACTURING OF BIOLOGICS

The present invention provides an adapted perfusion or continuous perfusion manufacturing process comprising an automated biomass-based controlled perfusion rate which ensures a more efficient process. Hence, a process according to the present invention is more manufacturing friendly and operational...

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Bibliographic Details
Main Author Khurshid, Madiha
Format Patent
LanguageEnglish
Published 18.08.2022
Subjects
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Summary:The present invention provides an adapted perfusion or continuous perfusion manufacturing process comprising an automated biomass-based controlled perfusion rate which ensures a more efficient process. Hence, a process according to the present invention is more manufacturing friendly and operational friendly. Also provided are an apparatus to perform such a process and a biologic produced by such a process. The process comprises a first control loop for measuring and regulating medium level in the bioreactor and a second control loop for measuring and regulating the biomass in the bioreactor, comprising a permittivity probe or a Raman probe. First and second control loops are integrated using an integration unit.
Bibliography:Application Number: US202017616234