Rank Pathway Inhibitors in Combination with CDK Inhibitors

Provided herein are pharmaceutical compositions comprising i) a RANK pathway inhibitor in combination with ii) a CDK inhibitor, and related methods. Provided herein are methods of increasing or restoring a responsiveness or sensitivity of a cancer cell to treatment with a CDK inhibitor and methods o...

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Bibliographic Details
Main Authors De Anjo Casimiro, Sandra Cristina Cara, Da Costa, Luis António Marques
Format Patent
LanguageEnglish
Published 23.06.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are pharmaceutical compositions comprising i) a RANK pathway inhibitor in combination with ii) a CDK inhibitor, and related methods. Provided herein are methods of increasing or restoring a responsiveness or sensitivity of a cancer cell to treatment with a CDK inhibitor and methods of treating a subject with a resistance or reduced sensitivity to treatment with a CDK inhibitor.
Bibliography:Application Number: US202017606103