MULTISPECIFIC BINDING PROTEINS

• Main Authors: Rainey, Godfrey Jonah Anderson, Prakash, Gayatri, Grotenbreg, Gijsbert Marnix, Yelensky, Roman, Busby, Michele Anne, Blair, Wade, Jooss, Karin, Hwang, Shan Liu
• Format: Patent
• Language: English
• Published: 26.05.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are HLA-PEPTIDE targets and multispecific antigen binding proteins that bind HLA-PEPTIDE targets. Provided herein is an isolated multispecific antigen binding protein (ABP), comprising: a first antigen binding domain (ABD) that specifically binds to a human leukocyte antigen (HLA)-PEPTIDE target; and an additional ABD that specifically binds an additional antigen, wherein the HLA-PEPTIDE target comprises an HLA-restricted peptide complexed with an HLA Class I molecule, wherein the HLA-restricted peptide is located in the peptide binding groove of an α1/α2 heterodimer portion of the HLA Class I molecule, and wherein the HLA-PEPTIDE target is selected from Table A, Table A1, or Table A2.