MULTISPECIFIC BINDING PROTEINS

Provided herein are HLA-PEPTIDE targets and multispecific antigen binding proteins that bind HLA-PEPTIDE targets. Provided herein is an isolated multispecific antigen binding protein (ABP), comprising: a first antigen binding domain (ABD) that specifically binds to a human leukocyte antigen (HLA)-PE...

Full description

Saved in:
Bibliographic Details
Main Authors Rainey, Godfrey Jonah Anderson, Prakash, Gayatri, Grotenbreg, Gijsbert Marnix, Yelensky, Roman, Busby, Michele Anne, Blair, Wade, Jooss, Karin, Hwang, Shan Liu
Format Patent
LanguageEnglish
Published 26.05.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:Provided herein are HLA-PEPTIDE targets and multispecific antigen binding proteins that bind HLA-PEPTIDE targets. Provided herein is an isolated multispecific antigen binding protein (ABP), comprising: a first antigen binding domain (ABD) that specifically binds to a human leukocyte antigen (HLA)-PEPTIDE target; and an additional ABD that specifically binds an additional antigen, wherein the HLA-PEPTIDE target comprises an HLA-restricted peptide complexed with an HLA Class I molecule, wherein the HLA-restricted peptide is located in the peptide binding groove of an α1/α2 heterodimer portion of the HLA Class I molecule, and wherein the HLA-PEPTIDE target is selected from Table A, Table A1, or Table A2.
Bibliography:Application Number: US202017426627