Mechanosynthesis of a Co-Amorphous Formulation of Creatine with Citric Acid and Humidity-Mediated Transformation into a Co-Crystal

The present invention includes a co-crystal of creatine and citric acid obtained by milling, methods of making the same that include a process for the preparation of co-amorphous formulation of creatine and citric acid, the process comprising: mixing creatine and citric acid; milling the creatine an...

Full description

Saved in:
Bibliographic Details
Main Authors Pekar, Kyle B, Lefton, Jonathan B, Runchevski, Tomche
Format Patent
LanguageEnglish
Published 24.03.2022
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:The present invention includes a co-crystal of creatine and citric acid obtained by milling, methods of making the same that include a process for the preparation of co-amorphous formulation of creatine and citric acid, the process comprising: mixing creatine and citric acid; milling the creatine and citric acid for a time sufficient to form a co-amorphous solid, which co-amorphous solid can be converted into a co-crystal, and nutritional supplements that include the same.
Bibliography:Application Number: US202117484420