INHIBITORY CHIMERIC ANTIGEN RECEPTORS

The invention relates to an inhibitory chimeric antigen receptor (N-CAR) comprisingan extracellular domain comprising an antigen binding domain,a transmembrane domain, and,an intracellular domainwherein the intracellular domain comprises an Immunoreceptor Tyrosine-based Switch Motif ITSM, wherein sa...

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Bibliographic Details
Main Authors Juillerat, Alexandre, Stone, Donna Marie, Poirot, Laurent, Potluri, Shobha Chowdary, Pertel, Thomas Charles, Sasu, Barbra Johnson, RAJPAL, ARVIND
Format Patent
LanguageEnglish
Published 03.02.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention relates to an inhibitory chimeric antigen receptor (N-CAR) comprisingan extracellular domain comprising an antigen binding domain,a transmembrane domain, and,an intracellular domainwherein the intracellular domain comprises an Immunoreceptor Tyrosine-based Switch Motif ITSM, wherein said ITSM is a sequence of amino acid TX1YX2X3X4, whereinX1 is an amino acidX2 is an amino acidX3 is an amino acid andX4 is V or I.
Bibliography:Application Number: US202117385805